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KMID : 0386520120200020041
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Research Institute of Korean Medicone
2012 Volume.20 No. 2 p.41 ~ p.52
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Effect of CST on atopic dermatitis related inflammatory
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Kim Hye-Rim
Gim Seon-Bin
Yun Mi-Young
Lee Ki-Moo
Kim Dong-Hee
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Abstract
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In vitro tests were performed using CST to investigate its role on oxidative damages and inflammatory cytokines. 90% or higher cell viability was observed in CST treated groups from 25 to 200 using Raw 264.7 cells. CST showed dose-dependent DPPH scavenging activity, with 91.3% and 92.2% scavenging activities at 400 and 800 concentrations, respectively. CST showed dose-dependent suppression activity of ROS production, especially at 200 of 41.3%. CST decreased NO production activity, with significant decrease of 16.2% and 33.5% at 100 and 200 concentrations, respectively. IL-, IL-6, MCP-1 production rate were significantly decreased by 30.0%, 27.2%, 22.1% when Raw 264.7 cells were treated with LPS and with CST of 200 . Also, TNF- production rate was decreased by 28.6%. The results above indicated therapeutic effect of CST on the AD through anti-oxidative and immune modulatory effect. Various blending of drug substances with CST should be clinically tested.
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KEYWORD
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CST(Chunggisodoktang), atopic dermatitis, oxidative damages, inflammation
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